Non-genetic defects do not involve genes. Non-Genetic Inheritance (NGI) broadly encompasses various epigenetic, cytoplasmic, and other processes. Inherited gene regulation (IGR) is a term that encompasses a wide range of heritable variables that might affect child gene expression. Three characteristics of NGI systems must be understood: they are functionally dependent on DNA sequence information rather than being separate from it; the precise mechanisms are highly diverse; and they act probabilistically rather than as ‘epialleles’ with defined genomic locations and effects.
Significant genetic causality may now be ruled out with a high degree of certainty for diseases including heart disease, stroke, cancer, diabetes, disorders like autism, ADHD, and dementia, as well as mental illnesses like schizophrenia and depression. Stress concerns, low nutrition impacts, old age marriage, infertility issues, and sexually transmitted diseases are the most common and highly occurred non-genetic defects.
